| 1954 | Pfizer Philippines was officially established with 9 colleaguesQuality Improvement Pfizer partnered with Metro Drug Corporation to import and distribute Pfizer products. Back then, Metro Drug had a sales force of only three people.Ludwig A. Armerding was Pfizer PH's first ever country manager. |
| 1957 | A Pfizer manufacturing plant was constructed on Malugay Street in Makati City. This plant continued to operate for the next 24 years. It was the 9th of 81 manufacturing facilities established by Pfizer outside the U.S. |
| 1958 | Pfizer PH workforce grew from 9 to 159, following the organization of the Agricultural Division. |
| 1965 | The workforce increased to 239 |
| 1967 | Vibramycin, one of the most important broad-spectrum antibiotics, was launched. |
| 1971 | Combantrin, a popular anti-parasitic medicine for children, was launched. |
| 1978 | Pfizer medicines started to be pack in blister packs. |
| 1984 | Lysivit Multivitamin syrup was launched. |
| 1993 | The first Filipino country manager was Federico A. Gonzalez. He served from 1993 to 1996, and mentored Rey Gerardo E. Bacarro, who would later on serve as the country manager in 2001. |
| 1994 | Pfizer launched Zithromax, the first oral antibiotic for respiratory tract, skin, and soft tissue infections. |
| 1997 | Sandra Webb became the first female country manager. She was also responsible for setting up the Pfizer Philippines Foundation. |
| 1998 | Pfizer launched Viagra and Trovan. The company already had 384 employees. |
| 1999 | Celebrex debuted. |
| 2000 | The biggest merger in global pharmaceutical history took place when Pfizer acquired Warner LambertThe company became number one in the cardiovascular business owing to its "crown jewels," Norvasc and Lipitor |
| 2001 | Pfizer Philippines was named as one of the Best Employers in the Philippines be Hewitt Associates, Asian Wall Street Journal, and the Far Eastern Economic Review |
| 2002 | Pfizer acquired Pharmacia Corporation and officially combined operations in April 2003 |
| 2004 | Pfizer celebrated its 50th anniverary in the Philippines.The Pfizer SulitCard was also launched. |
| 2005 | ENGAGE, one of the programs of the Pfizer Philippines Foundation, was conceived after a company-wide survey showed that majority of colleagues value employee volunteerism. ENGAGE went on to receive several awards from PR and CSR award-giving bodies. |
| 2008 | Terramycin Wound Wash was launched. It complemented Terramycin Plus Skin Antibiotic, allowing Pfizer to offer a complete wound care system. |
| 2009 | In October 15, Pfizer acquired Wyeth |
| 2010 | Normetec, a treatment for hypertension and Prevenar 13, the now-number one vaccine in the world, were introduced to the Philippine Market |
| 2011 | Pristiq, an anti-depressant, debuted |
| 2012 | The NayBahay Birthing Center program was launched by the Pfizer Philippines Foundation to provide safe birthing facilities and affordable maternal healthcare services for women especially in remote areas. The first NayBahay Ligtas Paanakan Center was established in Minalabac, Camarines Sur. |
| 2013 | The FDA approved the use of Prevenar 13 for all ages, 6 weeks onwards.Pfizer launched Eliquis, a significant breakthrough in anticoagulation since the discovery of warfarin more than 50 years ago. |
| 2014 | Violi D. Remo became the first Filipina Country Manager2014 marks Ponstan's 50th year and Pfizer Sulit Care Card's 10th year in the PhilippinesPfizer Philippines Celebrated its 60th year in August 3160 Years, 60 Homes: Pfizer celebrates anniverary with Yolanda survivors |
| 2015 | In February, Pfizer acquired Hospira, the largest producer of generic injectable pharmaceuticals in the world |
| 2018 | Pfizer announced it will organize the company into three business: a science-based Innovative Medicines business which will now include biosimilars and a new hospital business unit for anti-infectives and sterile injectibles (PBG); an off-patent branded and generic Established Medicines business operating with substantial autonomy within Pfizer (Upjohn) and a Consumer Healthcare business (PCH)In December 2018, GlaxoSmithKline announced that it, along with Pfizer, had reached an agreement to merge and combine their consumer healthcare divisions into a single entity |
| 2019 | In late July, Mylan N.V. and Pfizer Inc. agreed to combined Mylan with Upjohn, creating a new global pharmaceutical company |
| 2021 | Pfizer and BioNTech to Supply Phillipines with COVID-19 mRNA vaccine (BNT162b2) - Comirnaty to Combat COVID-19 |
| 2023 | Medical Drone Project Recognition: Pfizer Philippines, through its foundation (PPFI), received the Outstanding Project in Health award at the 2023 League of Corporate Foundations (LCF) CSR Guild Awards for its medical drone delivery initiative |
| 2024 | Pfizer Philippines celebrated its 70th year on August 31, 2024, commemorating its founding in 1954 |